研究業績

  1. Tanaka T, Saito A, Suzuki T, Miyamoto Y, Takayama K, Okamoto T, Moriishi K. Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening. Antiviral Res. 199:105268. (2022) (IF: 5.801)
  2. Zhang H, Itoh Y, Suzuki T, Ihara KI, Tanaka T, Haga S, Enatsu H, Yumiya M, Kimura M, Takada A, Itoh D, Shibazaki Y, Nakao S, Yoshio S, Miyakawa K, Miyamoto Y, Sasaki H, Kajita T, Sugiyama M, Mizokami M, Tachibana T, Ryo A, Moriishi K, Miyoshi E, Kanto T, Okamoto T (corresponding author), Matsuura Y. Establishment of monoclonal antibodies broadly neutralize infection of hepatitis B virus. Microbiol Immunol. Jan 27. (2022) (IF: 1.917)
  3. Tsuji S, Minami S, Hashimoto R, Konishi Y, Suzuki T, Kondo T, Sasai M, Torii S, Ono C, Shichinohe S, Sato S, Wakita M, Okumura S, Nakano S, Matsudaira T, Matsudaira T, Matsumoto T, Kawamoto S, Yamamoto M, Watanabe T, Matsuura Y, Takayama K, Kobayashi T, Okamoto T, Hara E. SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response, Nature Aging. 2:115-124 (2022)
  4. Deguchi S, Shintani T, Harada K, Okamoto T, Takemura A, Hirata K, Ito K, Takayama K, Mizuguchi H. In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology. Hepatol Commun. 2021 May 5;5(8):1385-1399.
  5. Saito A*, Shofa M, Ode H, Yumiya M, Junki Hirano, Okamoto T*, Yoshimura SH*. How do Flaviviruses hijack host cell function by phase separation? Viruses. 2021,13, 1479 *corresponding authors
  6. Yoshida Y, Yoshio S, Yamazoe T, Mori T, Tsustui Y, Kawai H, Yoshikawa S, Fukuhara T, Okamoto T, Ono Y, Takahashi Y, Hashida R, Kawaguchi T, Taketomi A, Kanto T. Phenotypic Characterization by Single-Cell Mass Cytometry of Human Intrahepatic and Peripheral NK Cells in Patients with Hepatocellular Carcinoma. Cells. 2021 Jun 14;10(6):1495. doi: 10.3390/cells10061495.
  7. Higuchi Y, Suzuki T, Arimori T, Ikemura N, Mihara E, Kirita Y, Ohgitani E, Mazda O, Motooka D, Nakamura S, Sakai Y, Itoh Y, Sugihara F, Matsuura Y, Matoba S, Okamoto T*, Takagi J*, Hoshino A*, Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2. Nat Commun. 12, 3802 (2021) Published: 21 June 2021. *corresponding authors
  8. Hirano J, Yoshio S, Sakai Y, Songling L, Suzuki T, Itoh Y, Zhang H, Chen DV, Haga S, Oomori H, Kodama T, Maeda Y, Ono Y, Takahashi Y, Standley DM, Yamamoto M, Moriishi K, Moriya K, Kanto T, Takehara T, Koike K, Matsuura Y, Okamoto T. Hepatitis C virus modulates signal peptide peptidase to alter host protein processing. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2026184118. doi: 10.1073/pnas.2026184118
  9. Joshita S, Yamashita Y, Okamoto T, Usami Y, Sugiura A, Yamazaki T, Kakino A, Ota M, Sawamura T, Umemura T. Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using direct-acting antivirals. Hepatol Res. 2021 May 13. doi: 10.1111/hepr.13666.
  10. Roy MJ, Vom A, Okamoto T, Smith BJ, Birkinshaw RW, Yang H, Abdo H, White CA, Segal D, Huang DCS, Baell JB, Colman PM, Czabotar PE, Lessene G. Structure- Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2. J Med Chem. 2021 May 13;64(9):5447-5469. doi: 10.1021/acs.jmedchem.0c01771.
  11. Nakae A, Kodama M, Okamoto T, Tokunaga M, Shimura H, Hashimoto K, Sawada K, Kodama T, Copeland NG, Jenkins NA, Kimura T. Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl- diphosphate farnesyltransferase 1. Biochem Biophys Res Commun. 2021 May 7;552:120-127. doi: 10.1016/j.bbrc.2021.03.049.
  12. Chen DV, Suzuki T, Itoh Y, Maeda Y, Hirano J, Haga S, Zhang H, Ito D, Matsuura Y, Okamoto T. Deneddylation by SENP8 restricts hepatitis B virus propagation. Microbiol Immunol. 2021 Mar;65(3):125-135. doi: 10.1111/1348-0421.12874.
  13. Fauzyah Y, Ono C, Torii S, Anzai I, Suzuki R, Izumi T, Morioka Y, Maeda Y, Okamoto T, Fukuhara T, Matsuura Y. Ponesimod suppresses hepatitis B virus infection by inhibiting endosome maturation. Antiviral Res. 2021 Feb;186:104999. doi: 10.1016/j.antiviral.2020.104999.
     
  14. Fukushima K, Satoh T, Sugihara F, Sato Y, Okamoto T, Mitsui Y, Yoshio S, Li S, Nojima S, Motooka D, Nakamura S, Kida H, Standley DM, Morii E, Kanto T, Yanagita M, Matsuura Y, Nagasawa T, Kumanogoh A, Akira S. Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis. Immunity. 2020 52(3):542-556.e13
  15. Djajawi TM, Liu L, Gong JN, Huang AS, Luo MJ, Xu Z, Okamoto T, Call MJ, Huang DCS, van Delft MF. MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex. Cell Death Differ. 2020 Feb 24. [Epub ahead of print]
  16. Tokunaga M, Miyamoto Y, Suzuki T, Otani M, Inuki S, Esaki T, Nagao C, Mizuguchi K, Ohno H, Yoneda Y, Okamoto T, Oka M, Matsuura Y. Novel Anti-Flavivirus Drugs Targeting the Nucleolar Distribution of Core Protein. Virology. 2020 541:41-51
  17. Tamura T, Igarashi M, Enkhbold B, Suzuki T, Okamatsu M, Ono C, Mori H, Izumi T, Sato A, Fauzyah Y, Okamoto T, Sakoda Y, Fukuhara T, Matsuura Y. In vivo dynamics of reporter Flaviviridae viruses.  J Virol. 2019 Aug 28. pii: JVI.01191-19.
  18. Bando H, Pradipta A, Iwanaga S, Okamoto T, Okuzaki D, Tanaka S, Vega-Rodríguez J, Lee Y, Ma JS, Sakaguchi N, Soga A, Fukumoto S, Sasai M, Matsuura Y, Yuda M, Jacobs-Lorena M, Yamamoto M. CXCR4 regulates Plasmodium development in mouse and human hepatocytes. J Exp Med. Aug 5;216(8):1733-1748 (2019)
  19. Mano Y, Yoshio S, Shoji H, Tomonari S, Aoki Y, Aoyanagi N, Okamoto T, Matsuura Y, Osawa Y, Kimura K, Yugawa K, Wang H, Oda Y, Yoshizumi T, Maehara Y, Kanto T. Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma. J Gastroenterol. Apr 2. (2019)
  20. Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, He Z, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T (Corresponding author), Matsuura Y.
    USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation.
    J Virol. Jan 9. pii: JVI.01708-18 (2019)
  21. Deng L, Gan X, Ito M, Chen M, Aly HH, Matsui C, Abe T, Watashi K, Wakita T, Suzuki T, Okamoto T, Matsuura Y, Mizokami M, Shoji I, Hotta H.
    Peroxiredoxin 1, a novel HBx-interacting protein, interacts with Exosc5 and negatively regulates HBV propagation through degradation of HBV RNA.
    J Virol. Dec 19. pii: JVI.02203-18 (2018)
  22. Mori H, Fukuhara T, Ono C, Tamura T, Sato A, Fauzyah Y, Wada M, Okamoto T, Noda T, Yoshimori T, Matsuura Y.
    Induction of selective autophagy in cells replicating hepatitis C virus genome.
    J Gen Virol. Dec;99(12):1643-1657 (2018)
  23. Suzuki T, Okamoto T (Corresponding author), Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Fukuhara T, Ikawa M, Satoh T, Yoshio S, Suzuki R, Saijo M, Huang DCS, Kanto T, Akira S, Matsuura Y.
    Infection with flaviviruses requires BCLXL for cell survival.
    PLoS Pahog. 14(9):e1007299 (2018)
  24. Priyambada SA, Misaki R, Okamoto T, Ohashi T, Ueda K, Matsuura Y, Fujiyama K.
    St6gal1 knockdown alters HBV life cycle in HepAD38 cells.
    Biochem Biophys Res Commun. 503(3), 1841-47 (2018)
  25. Oka H, Masuno K, Uehara T, Okamoto T, Matsuura Y, Nakano T, Yamaguchi S.
    Novel miRNA biomarkers for genotoxicity screening in mouse.
    Toxicology. Jul 1, 404-405: 68-75 (2018)
  26. Ono C, Hirano J, Okamoto T, Matsuura Y.
    Evaluation of viral contamination in a baculovirus expression system.
    Microbiol Immunol. 2018 Mar;62(3):200-204.
  27. Hirano J, Okamoto T (Corresponding author), Sugiyama Y, Suzuki T, Kusakabe S, Tokunaga M, Fukuhara T, Sasai M, Tougan T, Matsunaga Y, Yamashita K, Sakai Y, Yamamoto M, Horii T, Standley DM, Moriishi K, Moriya K, Koike K, Matsuura Y.
    Characterization of SPP inhibitors suppressing propagation of HCV and protozoa.
    Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10782-E10791.
  28. Tamura T, Fukuhara T, Uchida T, Ono C, Mori H, Sato A, Fauzyah Y, Okamoto T, Kurosu T, Setoh YX, Imamura M, Tautz N, Sakoda Y, Khromykh AA, Chayama K, Matsuura Y.
    Characterization of Recombinant Flaviviridae Viruses Possessing a Small Reporter Tag.
    J Virol. 2018 Jan 2;92(2). pii: e01582-17.
  29. Okamoto T, Suzuki T, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Matsuura Y.
    Regulation of apoptosis during Flavivirus infection.
    Viruses. 9(9) E243 (2017)
  30. Kurihara T, Fukuhara T, Ono C, Yamamoto S, Uemura K, Okamoto T, Sugiyama M, Motooka D, Nakamura S, Ikawa M, Mzokami M, Maehara Y, Matsuura Y.
    Suppression of HBV replication by the expression of nickase- and nuclease dead Cas9.
    Sci Rep 7(1):6122 (2017)
  31. Priyambada SA, Misaki R, Okamoto T, Okamoto Y, Ohashi T, Ueda K, Matsuura Y, Fujiyama K.
    Cell surface N-glycan alteration in HepAD38 cell lines expressing Hepatitis B virus.
    Virus Res. 15; 238:101-109 (2017)
  32. Fukuhara T, Tamura T, Ono C, Shiokawa M, Mori H, Uemura K, Yamamoto S, Kurihara T, Okamoto T, Suzuki R, Yoshii K, Kurosu T, Igarashi M, Aoki H, Sakoda Y, Matsuura Y.
    Host-derived apolipoproteins play comparable roles with viral secretory proteins Erns and NS1 in the infectious particle formation of Flaviviridae.
    Plos Pathog. Jun 23; 13(6):e1006475 (2017)
  33. Ono C, Fukuhara, T, Motooka D, Nakamura S, Okuzaki D, Yamamoto S, Tamura T, Mori H, Sato A, Uemura K, Fauzyah Y, Kurihara T, Suda T, Nishio A, Hmwe SS, Okamoto T, Tatsumi T, Takehara T, Chayama K, Wakita T, Koike K, Matsuura Y.
    Characterization of miR-122-independent propagation of HCV.
    PLoS Pathog. May 11; 13(5):e1006374 (2017)
  34. Uehara A, Murayama T, Yasukochi M, Fill M, Horie M, Okamoto T, Matsuura Y, Uehara K, Fujimoto T, Sakurai T, Kurebayashi N.
    Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity.
    J Gen Physiol. 149(2):199-218 (2017)
  35. Tanaka T, Okuyama-Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, Hosoya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M, Moriishi K.
    Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation.
    Antiviral Res. 133:156-64 (2016)
  36. Puig-Basagoiti F, Fukuhara T, Tamura T, Ono C, Uemura K, Kawachi Y, Yamamoto S, Mori H, Kurihara T, Okamoto T, Aizaki H, Matsuura Y.
    Human Cathelicidin Compensates for the Role of Apolipoproteins in Hepatitis C Virus Infectious Particle Formation.
    J Virol. 90(19): 8464-77 (2016)
  37. Yamamoto S, Fukuhara T, Ono C, Uemura K, Kawachi Y, Shiokawa M, Mori H, Wada M, Shima R, Okamoto T, Hiraga N, Suzuki R, Chayama K, Wakita T, Matsuura Y.
    Lipoprotein receptors redundantly participate in entry of hepatitis C virus.
    PLoS Pathog. May 6;12(5):e1005610 (2016)
  38. Masuda K, Ripley B, Nyati KK, Dubey PK, Zaman NN, Hanieh H, Higa M, Yamashita K, Standley DM, Mashima T, Katahira M, Okamoto T, Matsuura Y, Takeuchi O, Kishimoto T.
    Arid5a regulates naïve CD4+ T-cell fate through selective stabilization of Stat3 mRNA.
    J Exp Med. 213(4):605 (2016)
  39. Aizawa S, Okamoto T (Co-first), Sugiyama Y, Kouwaki T, Ito A, Suzuki T, Ono C, Fukuhara T, Yamamoto M, Okochi M, Hiraga, M, Imamura M, Chayama K, Suzuki R, Shoji I, Moriishi K, Moriya K, Koike K, Matsuura Y.
    TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.
    Nat Commun. 7: 11379 (2016)
  40. Kouwaki T, Okamoto T (Co-first), Ito A, Sugiyama Y, Yamashita K, Suzuki T, Kusakabe S, Hirano J, Fukuhara T, Yamashita A, Saito K, Okuzaki D, Watashi K, Sugiyama M, Yoshio S, Standley DM, Kanto T, Mizokami M, Moriishi K, Matsuura Y.
    Hepatocyte factor JMJD5 regulates HBV replication through interaction with HBx.
    J Virol. 90(7) 3530-3542 (2016)
  41. Shima R, Li TC, Sendai Y, Kataoka C, Mori Y, Abe T, Takeda N, Okamoto T, Matsuura Y.
    Production of hepatitis E virus-like particles presenting multiple foreign epitopes by co-infection of recombinant baculoviruses.
    Sci Rep. Feb 24(6):21638 (2016)
  42. Yoshio S, Sugiyama M, Shoji H, Mano Y, Mita E, Okamoto T, Matsuura Y, Okuno A, Takikawa O, Mizokami M, Kanto T.
    Indoleamine-2, 3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.
    Hepatology Jan;63(1):83-94 (2016)
  43. Dobashi-Okuyama K, Kasai H, Tanaka T, Yamashita A, Yasumoto J, Chen W, Okamoto T, Maekawa S, Watashi K, Wakita T, Ryo A, Suzuki T, Matsuura Y, Enomoto N, Moriishi K.
    Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide.
    Sci Rep. Nov 23(5):17047 (2015)
  44. Kasai K, Kawakami K, Yokoe H, Yoshimura K, Matsuda M, Yasumoto J, Maekawa S, Yamashita A, Tanaka T, Ikeda M, Kato N, Okamoto T, Matsuura Y, Sakamoto N, Enomoto N, Takeda S, Fujii H, Tsubuki M, Kusunoki M, Moriishi K.
    Involvement of FKBP6 in hepatitis C virus replication.
    Sci Rep. Nov 16(5):16699 (2015)
  45. Matsuhisa K, Yamane S, Okamoto T, Watari A, Kondoh M, Matsuura Y, Yagi K.
    Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin.
    Biochem Biophys Res Commun. Jun 19;462(1):52-7 (2015)
  46. Fukuhara T, Wada M, Nakamura S, Ono C, Shiokawa M, Yamamoto S, Motomura T, Okamoto T, Okuzaki D, Yamamoto M, Saito I, Wakita T, Koike K, Matsuura Y.
    Amphipathic α-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus Particles.
    PLoS Pathog. Dec 11;10(12):e1004534 (2014)
  47. Tanaka T, Kasai H, Yamashita A, Okuyama-Dobashi K, Yasumoto J, Maekawa S, Enomoto N, Okamoto T, Matsuura Y, Morimatsu M, Manabe N, Ochiai K, Yamashita K, Moriishi K.
    Hallmarks of hepatitis C virus in equine hepacivirus.
    J Virol. Nov;88(22):13352-66 (2014)
  48. Shiokawa M, Fukuhara T, Ono C, Yamamoto S, Okamoto T, Watanabe N, Wakita T, Matsuura Y.
    Novel permissive cell lines for complete propagation of hepatitis C virus.
    J Virol. 88(10): 5578-5594 (2014)
  49. Okamoto T, Segal D, Zobel K, Fedorova A, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE.
    Further insights into the effects of pre-organizing the BimBH3 helix.
    ACS Chem Biol. 9(3): 836-839 (2014)
  50. Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, Valente LJ, Robati M, Tai L, Fairlie WD, Lee EF, Lindstrom MS, Wiman KG, Huang DCS, Bouillet P, Rowe M, Rickinson AB, Herold MJ and Strasser A.
    Targetting of MCL-1 kills MYC-driven mouse and human lymphomas eve when they bear mutations in p53.
    Genes Dev. 28(1):58-70 (2014)
  51. *Okamoto T, Coultas L, Metcalf D, van Delft M, Glasser SP, Takiguchi M, Strasser A, Bouillet P, Adams JM, Hunag DCS.
    Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunt stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.
    Proc Natl Acad Sci USA 111(1): 261-266 (2014)
  52. Ono C, Ninomiya A, Yamamoto S, Abe T, Wen X, Fukuhara T, Sasai M, Yamamoto M, Saitoh T, Kawai T, Ishii KJ, Akira S, Okamoto T, Matsuura Y.
    Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.
    J Virol. 88(4) 2157-2167 (2014)
  53. Brumatti G, Salmanidis M, Kok CH, Bilardi RA, Sandow JJ, Silke N, Mason K, Visser J, Jabbour AM, Glaser SP, Okamoto T, Bouillet P, D'Andrea RJ, Ekert PG.
    HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia.
    Oncotarget. 4(11) 1933-47 (2013)
  54. Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS.
    The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism.
    Immunity. 39: 443-453 (2013)
  55. Kimura T, Katoh H, Kayama H, Saiga H, Okuyama M, Okamoto T, Umemoto E, Matsuura Y, Yamamoto M, Takeda K.
    Ifit1 inhibits JEV replication through binding to 5' capped 2'-O unmethylated RNA.
    J Virol. 87(18): 9997-10003 (2013)
  56. Salmanidis M, Brumatti G, Narayan N, Green BD, van den Bergen JA, Sandow JJ, Bert AG, Silke N, Sladic R, Puthalakath H, Rohrbeck L, Okamoto T, Bouillet P, Herold MJ, Goodall GJ, Jabbour AM, Ekert PG.
    Hoxb8 regulates expression of microRNAs to control cell death and differentiation.
    Cell Death Differ. 20(10): 1370-1380 (2013)
  57. Tripathi LP, Kambara H, Chen YA, Nishimura Y, Moriishi K, Okamoto T, Morita E, Abe T, Mori Y, Matsuura Y, Mizuguchi K.
    Understanding the Biological Context of NS5A-Host Interactions in HCV Infection: A Network-Based Approach.
    J Proteome Res. Jun 7;12(6):2537-51 (2013)
  58. Moujalled DM, Cook WD, Okamoto T, Murphy J, Lawlor KE, Vince JE, Vaux DL.
    TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.
    Cell Death Dis. Jan 17;4:e465 (2013)
  59. Okamoto T, Zobel K, Fedorova A, Quan C, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE.
    Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity.
    ACS Chem Biol. 8(2): 297-302 (2013)
  60. Katoh H, Okamoto T, Fukuhara T, Kambara H, Morita E, Mori Y, Kamitani W, Matsuura Y.
    Japanese Encephalitis Virus Core Protein Inhibits Stress Granule Formation through an Interaction with Caprin-1 and Facilitates Viral Propagation.
    J Virol. 87(1):489-502 (2012)
  61. Giam M, Okamoto T, Mintern JD, Strasser A, Bouillet P.
    Bcl-2 family member Bcl-G is not a proapoptotic protein.
    Cell Death Dis. Oct 11;3:e404 (2012)
  62. Okamoto T, Campbell S, Mehta N, Thibault J, Colman PM, Barry M, Huang DC, Kvansakul M.
    Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins.
    J Virol. 86(21): 11501-11. (2012)
  63. Yamamoto M, Okuyama M, Ma JS, Kimura T, Kamiyama N, Saiga H, Ohshima J, Sasai M, Kayama H, Okamoto T, Huang DC, Soldati-Favre D, Horie K, Takeda J, Takeda K.
    A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.
    Immunity. 37(2): 302-12. (2012)
  64. Kajiura H, Okamoto T, Misaki R, Matsuura Y, Fujiyama K.
    Arabidopsis β1,2-xylosyltransferase: substrate specificity and participation in the plant-specific N-glycosylation pathway.
    J Biosci Bioeng. 113(1): 48-53. (2012)
  65. Yamamoto M, Chistina M, Ma JS, Saiga H, Kamiyama N, Kubo E, Okamoto T, Ito H, Okuyama M, Kayama H, Takashima S, Matsuura Y, Favre DS, Takeda K.
    ATF6β is a host cellular target of the Toxoplasma virulence factor ROP18.
    J Exp Med. 208(7):1533-46. (2011)
  66. Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M, Liu J, Belmont LD, Kaminker J, O’Rourke KM, Pujara K, Kohli PB, Johnson AR, Chiu ML, Lill JR, Jackson PK, Fairbrother WJ, Seshagiri S, Ludlam MJC, Leong KG, Dueber E, Maecker H, Huang DCS, Dixit VM.
    Sensitivity to Antitubulin Chemotherapeutics is Regulated by Mcl1 and FBW7.
    Nature 471(7336): 110-114. (2011)
  67. Banadyga L, Lam SC, Okamoto T, Kvansakul M, Huang DC, Barry M.
    Deerpox Virus Encodes an Inhibitor of Apoptosis that Regulates Bak and Bax.
    J Virol. 85(5):1922-34. (2011)
  68. Kimura T, Imamura M, Hiraga N, Hatakeyama T, Miki D, Noguchi C, Mori N, Tsuge M, Takahashi S, Fujimoto Y, Iwao E, Ochi H, Abe H, Maekawa T, Arataki K, Tateno C, Yoshizato K, Wakita T, Okamoto T, Matsuura Y, Chayama K.
    Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice.
    J Gen Virol. 89: 2108-2113. (2008)
  69. Okamoto K, Mori Y, Komoda Y, Okamoto T, Okochi M, Takeda M, Suzuki T, Moriishi K, Matsuura Y.
    Intramembrane Processing by Signal Peptide Peptidase Regulates the Membrane Localization of Hepatitis C Virus Core Protein and Viral Propagation.
    J Virol. 82(17): 8349-8361. (2008)
  70. Okamoto T, Omori H, Kaname Y, Abe T, Nishimura Y, Suzuki T, Miyamura T, Yoshimori T, Moriishi K, Matsuura Y.
    A Single-Amino-Acid Mutation in Hepatitis C Virus NS5A Disrupting FKBP8 Interaction Impairs Viral Replication.
    J Virol. 82(7): 3480-3489. (2008)
  71. Taguwa S, Okamoto T, Abe T, Mori Y, Suzuki T, Moriishi K, Matsuura Y.
    Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication.
    J Virol. 82(6): 2631-2641. (2008)
  72. Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S.
    Enhanced TLR-mediated NF-IL6–dependent, gene expression by Trib1 deficiency. J Exp Med. 204(9): 2233-2239. (2007)
  73. Okamoto T, Nishimura Y, Ichimura T, Suzuki K, Miyamura T, Suzuki T, Moriishi K, Matsuura Y.
    Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.
    EMBO J. 25: 5015-5025. (2006)
  74. Nakai K, Okamoto T, Kimura-Someya T, Ishii K, Lim CK, Tani H, Matsuo E, Abe T, Mori Y, Suzuki T, Miyamura T, Nunberg JH, Moriishi K, Matsuura Y.
    Oligomerization of Hepatitis C Virus Core Protein Is Crucial for Interaction with Cytoplasmic Domain of E1 Envelope Protein.
    J Virol. 80(22): 11265-11273. (2006)
  75. Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S.
    Key function for Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
    Nat Immunol. 7(9): 962-970. (2006)
  76. Tsuda Y, Mori Y, Abe T, Yamashita T, Okamoto T, Ichimura T, Moriishi K, Matsuura Y.
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